This case report describes the nutritional management of a middle aged female client diagnosed with Vogt-Koyanagi-Harada (VKH) disease, an autoimmune inflammatory disorder, with multiple co-existing metabolic and hormonal challenges.The client exhibited hypertension, progressive weight gain, dyslipidemia characterized by elevated triglycerides and low density lipoprotein (LDL) cholesterol, and irregular menstrual cycles.During the course of nutritional intervention, further clinical evaluation revealed an underlying hormonal imbalance, and the client was identified to be in the peri-menopausal phase, which became increasingly evident over a seven-month structured nutrition journey. A personalized therapeutic nutrition plan was implemented to address systemic inflammation, immune dysregulation, cardiometabolic abnormalities, and hormonal fluctuations, while supporting sustainable weight management. The intervention prioritized long-term metabolic and hormonal regulation over rapid weight loss, with periodic dietary modifications guided by clinical symptoms, biochemical markers, and peri-menopausal physiological changes. This case underscores the importance of individualized, root-cause based nutritional therapy in the management of autoimmune conditions complicated by metabolic and hormonal transitions, particularly in peri-menopausal women.